Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore.
نویسندگان
چکیده
An activity-based probe, containing an irreversibly locked GFP-like fluorophore, was synthesized and evaluated as an inhibitor of human cathepsins and, as exemplified with cathepsin K, it proved to be suitable for ex vivo imaging and quantification of cysteine cathepsins by SDS-PAGE.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 35 شماره
صفحات -
تاریخ انتشار 2013